An Introduction to Avermectin Transdermal Solution

Overview of Avermectin Transdermal Solution

Avermectin transdermal solution is a specialized formulation designed to deliver avermectin, a potent antiparasitic agent, through the skin for therapeutic effects. This method of delivery is particularly beneficial for treating various parasitic infections in animals.

Main Ingredient: Avermectin, a class of macrocyclic lactones derived from the bacterium Streptomyces avermitilis. It works by inhibiting the function of aspects of the nervous system within the parasite.

Properties: This product is a colorless to slightly yellowish, slightly viscous, transparent liquid.

 

Formulation Components of Avermectin Transdermal Solution

Active Ingredient: Avermectin.

Solvent: Facilitates the dissolution of avermectin and helps with skin absorption (e.g., alcohols, propylene glycol).

Penetration Enhancers: Compounds like oleic acid or surfactants that help the drug penetrate the skin barrier.

Stabilizers and Preservatives: To maintain the efficacy and shelf-life of the solution.

 

Functions and Uses of Avermectin Transdermal Solution

It is commonly employed in veterinary medicine for treating internal and external parasitic infections in livestock and pets.

Internal parasitic: nematodes, roundworms, etc.

External parasitic: scabies, lice, mites, fleas, etc.

 

How to Use Avermectin Transdermal Solution Correctly?

The usual dose is 0.1ml per 1kg of body weight.

Pour along the midline of the animal’s back (Note: Pour after removing the hair to achieve the desired effect).

Remember to administer the product in a well-ventilated area. Wear protective gloves and clothing while handling this product, and thoroughly wash your hands after application.

 

What are the Benefits of Avermectin Transdermal Solution?

1. Internal and External Deworming

On one hand, the medication can penetrate the skin and hair of the whole body through the sebaceous glands to kill external parasites throughout the body; on the other hand, the drug can enter the capillaries through the skin and penetrate the whole body, thus achieving the effect of expelling and killing parasites in the body.

2. Transdermal Delivery

The solution is designed to penetrate the skin barrier, allowing for systemic absorption. It can largely avoid injection pain, with no stress.

3. Controlled Release

Formulations can provide a steady release of the active ingredient, maintaining therapeutic levels over time.

4. Avoids Gastrointestinal Issues

Bypasses the digestive system, which can avoid the problem of oral drugs being degraded in the gastrointestinal tract and damaging the liver.

5. Local Treatment

The transdermal route allows for localized treatment, which can be beneficial in certain conditions.

6. Ease to Use

Compared to oral or injectable forms, the transdermal route is generally more convenient for animals, improving compliance.

7. Reduced Frequency

It may require less frequent dosing compared to other delivery methods.

8. Non-invasive

Transdermal formulations may provide a less invasive alternative to injections. It offers a more comfortable option for animals who dislike injections or have difficulty swallowing pills.

9. Good Compatibility

For total parasite control, this drug can be used alongside other anthelmintic treatments for certain parasitic infections.

 

Precautions to Take Care When Using Avermectin Transdermal Solution

Do NOT use Avermectin transdermal solution for animals that:

– has a known allergy or hypersensitivity to any of the ingredients.

– is sick, debilitated, or injured.

– is producing milk for human consumption.

– is a lactating animal.

– is an animal weighing less than 50kg or under 3 months old.

 

Other Issues Should Be Noticed When Using Avermectin Transdermal Solution

Safety and Toxicity

While avermectins are generally safe for mammals due to their low affinity for mammalian channels, they are highly toxic to aquatic organisms. Therefore, care must be taken to avoid contamination of water sources during use.

Side Effects

Local Reactions: Possible irritation, redness, or itching at the application site.

Systemic Effects: Though less likely, systemic side effects may occur if significant amounts of the drug are absorbed.

Considerations

Concomitant use with diethylcarbamazine may produce severe or fatal encephalopathy.

Avermectin can be sensitive to light and temperature, necessitating proper storage conditions to maintain efficacy.

Withdrawal Period

The withdrawal period is 31-49 days for meat. The exact duration will depend on local regulations.

 

Conclusion

Avermectin Transdermal Solution is manufactured and produced by Gnee Bio, a pharmaceutical company specializing in global distribution. Our focus on quality has made Gnee a market leader in many countries. In addition, we also offer a broad range of high-quality and cost-effective veterinary medications available for exportation. Looking to be your next veterinary drug partner here.