N,N-Dimethylacetamide CAS 127-19-5 DMAC

Chemical Name: N,N-Dimethylacetamide
CAS No.: 127-19-5
Molecular Formula: C4H9NO
Formula Weight: 87.12
EINECS: 204-826-4
Appearance: liquid

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Base

N,N-Dimethylacetamide, also known as acetyl dimethylamine or DMAC, is an aprotic, highly polar solvent with a slight ammonia odor. It has strong dissolving power and can dissolve a wide range of substances. It is miscible with water, aromatic compounds, esters, ketones, alcohols, ethers, benzene, and chloroform, and can activate compound molecules. Therefore, it is widely used as a solvent and catalyst.

Properties

Melting Point	-20 °C (lit.)
Boiling Point	164.5-166 °C (lit.)
Density	0.937 g/mL at 25 °C (lit.)
Vapor Density	3.89 (vs air)
Vapor Pressure	40 mm Hg (19.4 °C)
Refractive Index	n20/D 1.439 (lit.)
Flash Point	158 °F
Storage Conditions	Store below +30°C.
Solubility	Solubility in water >1000 g/l
Form	Liquid
Acidity Coefficient (pKa)	-0.41±0.70 (Predicted)
Color	Colorless to Pale Yellow
Odor (Odor)	Few ammonia odor
pH Value	4 (200g/l, H2O, 20℃)
pH Range of Acid-Base Indicator	4 at 200 g/l at 20 °C
Relative Polarity	6.3
Odor Threshold (Odor tdreshold)	0.76ppm
Explosive Limit	1.7-11.5% (V)
Water Solubility	Miscible
Maximum Wavelength (λmax)	λ: 270 nm Amax: 1.00 λ: 280 nm Amax: 0.30 λ: 290 nm Amax: 0.15 λ: 310 nm Amax: 0.05 λ: 320 nm Amax: 0.03 λ: 360-400 nm Amax: 0.01
Merck	14,3227
BRN	1737614
Exposure Limits	NIOSH REL: TWA 10 ppm (35 mg/m³), IDLH 300 ppm; OSHA PEL: TWA 10 ppm; ACGIH TLV: TWA 10 ppm (adopted).
Dielectric Constant	37.8 (25℃)
Stability	Stable. Flammable. Incompatible with strong oxidizers.
InChIKey	FXHOOIRPVKKKFG-UHFFFAOYSA-N
LogP	-0.77 at 25℃
Surface Tension	37.13mN/m at 293.15K
CAS Database	127-19-5(CAS DataBase Reference)
(IARC) Carcinogen Classification	2B (Vol. 123) 2020
NIST Chemical Information	Acetamide, N,N-dimetdyl-(127-19-5)
EPA Chemical Information	Dimetdylacetamide (127-19-5)

Applications

DMAC is primarily used as a solvent in the spinning of synthetic fibers (acrylonitrile) and polyurethane, as well as in the synthesis of polyamide resins. It is also used as an extractive distillation solvent for separating styrene from C8 fractions and is widely used in polymer films, coatings, and pharmaceuticals.

Currently, it is extensively used in the pharmaceutical and pesticide industries to synthesize antibiotics and pesticides. It can also be used as a reaction catalyst, electrolytic solvent, paint remover, and in various crystalline solvent adducts and complexes.

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